During the past several years tremendous advancements have been made in the field of pharmacology and therapeutics. While new therapeutic strategies are coming up, old ones are being improved by modifications, or being replaced with newer ones. The major topics covered in this book include: endothelins, current topics in cardiovascular research, molecular pharmacology, recent developments in cancer research, antioxidants, oxidants and human disease, herbal drugs, developments in neuropharmacology, myelin biology and demyelinating disease, pharmacovigilance, role of cytokines in health and disease, ocular pharmacology, detoxification of xenobiotics-biotransformation and transport, and several other topics of current interest. The aim of this book is to fulfill the needs of the basic and clinical researchers as well as the students, particularly related to areas of current interest in pharmacology and therapeutics.Preface. 1. Endothelial Dysfunction and Vascular Disease; P.M.Vanhoutte.2. Endothelin Receptors: Targets for drug development; A.Ray, et al.3. Role of Endothelins in Cardiovascular Disease; L.C.Katwa.4. The Diabetic Vasculature and Endothelin; D.A. Misurski, etal.5. Beneficial Effects of Renin-Angiotensin System Blockade in Myocardial Infarction; N.S. Dhalla, X. Guo.6. Role of Angiotensinogen in Human Hypertension; A. Kumar.7. Biological Function of Cardiac High Molecular Weight Calmodulin-binding Protein; R. Kakkar, et al.8. A Synthetic Calmodulin-binding Pel#R