Pocket Guide to Biomolecular NMR [Paperback]

Steering clear of quantum mechanics and product operators, Pocket Guide to Biomolecular NMR uses intuitive, concrete analogies to explain the theory required to understand NMR studies on the structure and dynamics of biological macromolecules. For example, instead of explaining nuclear spin with angular momentum equations or Hamiltonians, the books describes nuclei as bells in a choir, ringing at specific frequencies depending on the atom type and their surrounding electromagnetic environment.This simple bell analogy, which is employed throughout the book, has never been used to explain NMR and makes it surprisingly easy to learn complex, bewildering NMR concepts, such as dipole-dipole coupling and CPMG pulse sequences. Other topics covered include the basics of multi-dimensional NMR, relaxation theory, and Model Free analysis. The small size and fast pace of Pocket Guide to Biomolecular NMR makes the book a perfect companion to traditional biophysics and biochemistry textbooks, but the book's unique perspective will provide even seasoned spectroscopists with new insights and handy thought short-cuts.

Atomic Bells and Frequency Finders

Bonded Bells and Two-Dimensional Spectra

Neighboring Bells and Structure Bundles

Relaxation Theory Part One: Silencing of the Bells

Relaxation Theory Part Two: Moving Atoms and Changing Notes

Protein Dynamics.

Currently an Assistant Editor for the journal Cell, Michaeleen Doucleff obtained her PhD in Chemistry from the University of California, Berkeley while working in the lab of David E. Wemmer. Doucleff then became a Nancy Nossal postdoctoral fellow at the National Institute's of Health in the lab of G. Marius Clore. Throughout her career, she has used NMR spectroscopy and X-ray crystallography to characterize the structure and dynamics of transcription factors and their interaction with DNA.

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