Pre-Clinical and Clinical Methods in Brain Trauma Research [Hardcover]

This volume explores current viewpoints and knowledge gaps in the field of traumatic brain injury (TBI). The chapters in this book cover topics ranging from development of in vitro and animal TBI models, to diagnostic imaging and disease monitoring in patients. Designing pre-clinical and clinical trials is also discussed. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Practical and thorough, Pre-Clinical and Clinical Methods in Brain Trauma Research is a valuable resource for both scientists and clinical researchers interested in learning about important techniques and their applications in the field of TBI.

Traumatic Brain Injury.- Three-Dimensional In Vitro Brain Tissue Models.- Modeling Traumatic Brain Injury In Vitro.- Drosophila Model to Study Chronic Traumatic Encephalopathy.- Controlled Cortical Impact for Modeling Traumatic Brain Injury in Animals.- Fluid Percussion Model of Traumatic Brain Injury.- Development of a Rodent Model of Closed Head Injury: The Maryland Model.- Rodent Model of Primary Blast-Induced Traumatic Brain Injury: Guidelines to Blast Methodology.- Cognitive and Motor Function Assessments in Rodent Models of Traumatic Brain Injury.- Pre-Procedural Considerations and Post-Procedural Care for Animal Models with Experimental Traumatic Brain Injury.- Laser Capture Microdissection of Single Cells, Cell Populations, and Brain Regions Affected by Traumatic Brain Injury.- Rat Microglia Isolation and Characterization Using Multi-Parametric Panel for Flow Cytometric Analysis.- The Principles of Experimental Design and the Determination of Sample Size When Using Animal Models of TraulÃ3