Protein-Protein Interactions: Principles and Techniques: Volume I [Hardcover]

This book provides a comprehensive overview of the fundamental aspects of protein-protein interactions (PPI), including a detailed account of the energetics and thermodynamics involved in these interactions. It also discusses a number of computational and experimental approaches for the prediction of PPI interactions and reviews their principles, advantages, drawbacks, and the recent developments.

Further, it offers structural and mechanistic insights into the formation of protein-protein complexes and maps different PPIs into networks to delineate various pathways that operate at the cellular level. Lastly, it describes computational protein-protein docking techniques and discusses their implications for further experimental research. Given its scope, this book is a valuable resource for students, researchers, scientists, entrepreneurs, and medical/healthcare professionals.

Chapter 1. Structural and functional properties of proteins.- Chapter 2. Structural aspects of protein-protein interactions.- Chapter 3. Energetics aspects of protein-protein interactions (PPIs).- Chapter 4. Evolution-structure paradigm of protein complexes.- Chapter 5. Experimental methods for determination of protein-protein interactions.- Chapter 6. Prediction, analysis, visualization, and storage of protein-protein interactions using computational approaches.

Dr. Krishna Mohan Poluri is currently working as an Associate Professor at the Biotechnology Department, IIT-Roorkee. He completed his PhD at Tata Institute of Fundamental Research TIFR-Mumbai, and Postdoc at Rutgers University & the University of Texas Medical Branch (UTMB-Texas). His areas of expertise are protein biochemistry & biophysics, bio-molecular interactions, structural biology, glycoimmunology, bionanotechnology, and algal biotechnology. He has published more than 110 articles and editorials in various rlcl