Resistance to Photodynamic Therapy in Cancer [Paperback]

This volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches?to overcome resistance in tumor cells.

Introduction

1.?Basic and Clinical Aspects of photodynamic Therapy
Valentina Rapozzi and Giulio Jori

Mechanistic Aspects Involved in Resistance to PDT

2.?Mechanisms of Resistance to Photodynamic Therapy
Adriana G. Casas, Christian Perotti, Gabriela Di Venosa and Alicira Batlle

3.?Tumor Vascular Microenvironment Determines responsiveness to Photodynamic Therapy
Shannon M. Gallagher-Colombo, Jarod C. Finlay and Theresa M. Busch

4.?Autophagy Pathways Activated in Response to PDT Contribute to Cell Resistance Against ROS Damage
Abhishek D. Garg and Patrizia Agostinis

5.?Methods to isolate the Resistant Cells to Photodynamic Therapy
Alicia Zamarr?n, Sara E. Lucena, Nerea Salazar, Pedro Ja?n, Salvador Gonzalez, Yolanda Gilaberte and Angeles Juarranz

Specific Strategies to Sensitize Tumor CellC