Role of Capsaicin in Oxidative Stress and Cancer [Paperback]

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress and much more.

Preface
Chapter 1? Role of capsaicin in cancer prevention
Chapter 2? Role of death receptors belonging to the TNF
??????????????????family in capsaicin-induced apoptosis of tumor?
??????????????????cells
Chapter 3 Role of capsaicin in prostate cancer
Chapter 4 Capsaicin and the urinary bladder
Chapter 5 Inhibition of pancreatitis and carcinogenesis by
?????????????????capsaicin
Chapter 6?Cytochrome P450-dependent modification of
?????????????????capsaicinoids:? pharmacological inactivation and
???????????????? bioactivation mechanisms
Chapter 7 The cancer suppressing and promoting actions of
?????????????????capsaicin
Chapter 8 Oxidative stress by capsaicin in cancer

Capsaicin is a principal pungent ingredient of red chili peppers, first isolated in the early nineteenth century by Christian Friedrich Bucholz. Widely consumed as a spice in South Asia and Latin America, Cl“-