The Role of Nitric Oxide in Heart Failure [Paperback]

Research on nitric oxide (NO) is a very hot topic since 1998, when three prominent researchers were recognized by Nobel prize awards.

Addresses clinically pertinent issues related to nitric oxide in the pathophysiology and therapeutics of heart failure.

Chapters written by basic scientists and clinicians to emphasize translation character of research in nitric oxide.

An excellent reference source for researchers, practitioners and students.

Nitric oxide (NO) is one of the most remarkable biological molecules characterized at the turn of XX century. Small in size, but ubiquitous and complex in its network of molecular, cellular and organ inter- tions, NO plays an important role in mammalian and non-mammalian biology. The scope and versatility of NO actions on the biological systems range from neuromodulation and regulation of cardiovascular homeostasis to cell signaling and immunity. An impressive array of physiologic and pathologic reactions are controlled by or associated with changes in the biological specter of NO. The career of NO in science started from a handful of publications written before 1986 to more than 52,000 contributions at the end of 2002 (Pubmed, National Library of Medicine). More than 15,000 publications deal with the effects of NO in the cardiovascular system. The NO field has been recently knighted with the 1998 Nobel Prize in Medicine awarded to R.F. Furchgott, F. Murad and L.J. Ignarro.Foreword. Preface. Acknowledgements. Part I: NO and Pathophysiology of Heart Failure. Nitric Oxide in Heart Failure: Friend or Foe; B.I. Jugdutt. NO and the Vasculature: Where Does It Come from and What Does It Do? K.L. Andrews, C.R. Triggle, A. Ellis. Myocardial Contractile Effects of Nitric Oxide Walter; J. Paulus, J.G.F. Bronzwaer. Nitric Oxide, Platelet Function, Myocardial Infarction and Reperfusion Therapies; D. Alonso, M.W. Radomski. Nitric Oxide, Atherosclerosis and the Clinical Rl#A