Sliding Filament Mechanism in Muscle Contraction: Fifity Years of Research [Paperback]

Sliding Filament Mechanism in Muscle Contraction: Fifty Years of Research covers the history of the sliding filament mechanism in muscle contraction from its discovery in 1954 by H.E. Huxley through and including modern day research. Chapters include topics in dynamic X-ray diffraction, electron microscopy, muscle mechanisms, in-vitro motility assay, cardiac versus smooth muscle, motile systems, and much more.

Sliding Filament Mechanism at the Molecular Level.- Early Developments in Muscle Research and the Role of New Structural Technologies.- The Molecular Basis of Cross-Bridge Function.- Molecular Synchronization in Actomyosin Motors  From Single Molecule to Muscle Fiber Via Nanomuscle.- Distribution of Crossbridge States in Contracting Muscle.- X-Ray Diffraction Studies of Striated Muscles.- Conformational Change and Regulation of Myosin Molecules.- Mechanism of Muscle Contraction.- Driving Filament Sliding: Weak binding cross-bridge states, strong binding cross-bridge states, and the power stroke.- Mysteries about Amplitude and Efficiency of Cross-Bridge Powerstroke.- Sarcomere Dynamics, Stepwise Shortening and the Nature of Contraction.- Crossbridge Formation Detected by Stiffness Measurements in Single Muscle Fibres.- Non Cross-Bridge Stiffness in Skeletal Muscle Fibres at Rest and During Activity.- Natures Strategy for Optimizing Power Generation in Insect Flight Muscle.- Muscle Energetics.- From Crossbridges to Metabolism: System Biology for Energetics.- Energetics, Mechanics and Molecular Engineering of Calcium Cycling in Skeletal Muscle.- Heat, Phosphorus NMR and Microcalorimetry in Relation to the Mechanism of Filament Sliding.- How Two-Foot Molecular Motors May Walk.- Regulatory Mechanism and E-C Coupling.- Molecular Basis of Calcium Regulation of Striated Muscle Contraction.- Mechanisms of Calcium Release from the Sarcoplasmic Reticulum in Skeletal Muscle.- From Inward Spread olƒt