Systems Biology and Synthetic Biology [Hardcover]

The genomic revolution has opened up systematic investigations and engineering designs for various life forms. Systems biology and synthetic biology are emerging as two complementary approaches, which embody the breakthrough in biology and invite application of engineering principles. Systems Biology and Synthetic Biology emphasizes the similarity between biology and engineering at the system level, which is important for applying systems and engineering theories to biology problems. This book demonstrates to students, researchers, and industry that systems biology relies on synthetic biology technologies to study biological systems, while synthetic biology depends on knowledge obtained from systems biology approaches.Chapter 1: Introduction (Pengcheng Fu).

Chapter 2: Basics of Molecular Biology, Genetic Engineering and Metabolic Engineering (Michael X. Wang and Huidong Shi).

Chapter 3: High-Throughput Technologies and Functional Genomics (Henry Wang and Dorothea K. Thompson).

Chapter 4: Predicting the Lymph Node Status of Breast Cancer Tumors Using Gene Expression Patterns and Genomic Signal Processing (Gordon Okimoto).

Chapter 5: From Recombinant Genes to Recombinant Genomes for Systems Biology (Mitsuhiro Itaya).

Chapter 6: In silico Genome-scale Metabolic Models: The Constraint-based Approach and its Applications (Andrew Joyce and Bernhard Palsson).

Chapter 7: Mathematical Modeling of Genetic Regulatory Networks: Stress Responses in Escherichia coli (Delphine Ropers, Hidde de Jong, and Johannes Geiselmann).

Chapter 8: Systems Approaches in Molecular Diagnostics and Drug Development (Martin Latterich).

Chapter 9: Yeast as a Prototype for Systems Biology (Gautham Vemuri and Jens Nielsen).

Chapter 10: Construction and Applications of Genome-Scale In Silico Metabolic Models for Strain Improvement (Sang Yup LlcÙ