This book highlights advances and prospects of a highly versatile and dynamic research field: Therapeutic ultrasound. Leading experts in the field describe a wide range of topics related to the development of therapeutic ultrasound (i.e., high intensity focused ultrasound, microbubble-assisted ultrasound drug delivery, low intensity pulsed ultrasound, ultrasound-sensitive nanocarriers), ranging from the biophysical concepts (i.e., tissue ablation, drug and gene delivery, neuromodulation) to therapeutic applications (i.e., chemotherapy, sonodynamic therapy, sonothrombolysis, immunotherapy, lithotripsy, vaccination). This book is an indispensable source of information for students, researchers and clinicians dealing with non-invasive image-guided ultrasound-based therapeutic interventions in the fields of oncology, neurology, cardiology and nephrology.
Part I High Intensity Focused Ultrasound Ablation of Pathological Tissue.- Chapter 1. HIFU Tissue Ablation: Concept & Devices G. Ter Haar.- Chapter 2. Prostate Focused Ultrasound Therapy J.Y. Chapelon, O. Rouvi?re, S. Crouzet, A. Gelet.- Chapter 3. MRI-guided HIFU Methods for the Ablation of Liver and Renal Cancers B.D. de Senneville, C. Moonen, M. Ries.- Chapter 4. Magnetic Resonance-guided High Intensity Focused Ultrasound Ablation of Breast Cancer.- F.M. Knuttel, M.A.A.J. van den Bosch.- Chapter 5. HIFU for Palliative Treatment of Pancreatic Cancer.- T.D. Khokhlova, J.H. Hwang.- Chapter 6. MR-guided Transcranial Focused Ultrasound.- J.F. Aubry, M. Tanter.- Chapter 7. Focused Ultrasound & Lithotripsy.- T. Ikeda, S. Yoshizawa, N. Koizumi, M. Mitsuishi, Y. Matsumoto.- Chapter 8. Heat-based Tumor Ablation: Role of the Immune Response F. Wu.- Part II Drug and Gene Delivery using Bubble-assisted Ultrasound.- Chapter 9. Droplets, Bubbles and Ultrasound Interactions O. Shpak, M. Verweij, N. de Jong, M. Versluis.- Chapter 10. Sonoporation: Concept and Mechanisms A. Bouakaz, A. Zeghimi, A.A. Doinikol³¹