Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition [Paperback]

Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition explores thiamine and how its deficiency affects the functions of the brainstem and autonomic nervous system by way of metabolic changes at the level of the mitochondria. Thiamine deficiency derails mitochondrial oxidative metabolism and gives rise to the classic disease of beriberi that, in its early stages, can be considered the prototype for a set of disorders that we now recognize as dysautonomia. This book represents the life's work of the senior author, Dr. Derrick Lonsdale, and a recent collaboration with his co-author Dr. Chandler Marrs.

• Presents clinical experience and animal research that have answered questions about thiamine chemistry
• Demonstrates that the consumption of empty calories can result in clinical effects that lead to misdiagnosis
• Addresses the biochemical changes induced by vitamin deficiency, particularly that of thiamine

1. The History of Thiamine and Beriberi 2. The Autonomic Nervous System and its Functions 3. Mitochondria, Thiamine and Autonomic Dysfunction 4. Evaluation and Treatment of Thiamine Metabolism in Clinical Practice 5. Thiamine Deficient Dysautonomias: Case Insights and Clinical Clues 6. High Calorie Malnutrition and Its Impact on Health 7. The Three Circles of Health 8. Energy Metabolism in a Revised Medical Model

A presentation of the latest research on high calorie malnutrition and thiamine deficiency, which contribute to many pediatric illnesses

Dr. Lonsdale was educated in England, graduating from London University with the degree MB BS. After National Service in the RAF as a medical officer he became a family physician under the National Health Service. He immigrated to Canada in 1957 and in 1960 he was accepted as a pediatric resident at Cleveland Clinic, Cleveland, Ohio. In l«