Toxicity and Autophagy in Neurodegenerative Disorders [Paperback]

Comprehensive overview of different aspects of autophagy as it relates to neurodegenerative diseases. The pathogenesis of the main neurodegenerative disorders includes either the accumulation of altered or misfolded proteins or exposure to several toxics. Autophagy constitute one of the two principal cellular pathways implicate in the clearance of these material and can serve as a neuroprotective mechanism. Topics include: the role of autophagy in the brain, the role of autophagy in the principal neurodegenerative disorders, and the mechanism by which different molecules cause neurotoxicity and the role autophagy plays.

Regulation of Autophagy In Health And Disease.- Role of Chaperone-Mediated Autophagy in Ageing and Neurodegeneration.- Interaction Between Mitochondria And Autophagy.- Dual role of autophagy in neurodegenerative diseases: The case of amyotrophic lateral sclerosis.- Autophagy pathways in Huntingtons disease.- Control of Autophagy in Parkinsons Disease.- Autophagy in Alzheimers disease: a cleaning service out-of-order?.- Autophagy as a neuroprotective mechanism against 3-nitropropionic acid-induced cell death.- Paraquat: Molecular Mechanisms of Neurotoxicity and its Relation with Autophagy.- Agrochemicals-induced Dopaminergic Neurotoxicity:? Role of Mitochondria-mediated oxidative stress and Protein Clearance Mechanisms.- Molecular And Neurochemical Mechanisms Dopamine Oxidation To O-Quinones In Parkinson?S Disease Pathogenesis.- Exploring the Role of Autophagy in the Pathogenesis of Rotenone-Induced Toxicity.-? Autophagic pathology and calcium deregulation in neurodegeneration.

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This is a very good book for students andresearchers involved with biochemical and cellular pathways of immune responsesafter cell toxicity due to neurodegenerative processes. I highly recommend thebook to neurologists, physiologists, and biochemists. (Joseph J.  Grenier, Amazon.com, January, 2016)

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