Public-private collaborations are key to the functioning of most essential ecosystems such as security, healthcare, education, and energy. William B. Rouse addresses the challenges of transforming these ecosystems and provides an integrated perspective for understanding and enabling change.Public-private collaborations are central to the functioning and provisioning of most essential ecosystems. Ecosystems such as security, healthcare, education, and the environment face challenges of governance, diverse constituencies, numerous advocacy organizations, incompatible outcome metrics, and persistent media attention, to name a few. There is a wide range of public and private players involved in operating, sustaining, and investing in these ecosystems, including stakeholders from government, industry, academia, non-governmental organizations, and the general public.Fundamental change requires understanding a wide range of interests and accommodating change strategies accordingly. The challenges of transforming these ecosystems would easily qualify as wicked problems; social or cultural problems laced with incomplete or contradictory knowledge, large numbers of people and opinions, substantial economic burdens, and inextricable connections with other issues.Transforming Public-Private Ecosystemsaddresses these challenges for the four important ecosystems of national security, healthcare delivery, higher education, and energy and climate, and provides an integrated perspective for understanding and enabling change.1. Ecosystems, Innovation, and Transformation2. Wicked Problems and Human-Centered Design3. National Security4. Healthcare Delivery5. Higher Education6. Energy and Climate7. Across Ecosystems8. Enabling ChangeWilliam B. Rouse,Research Professor, Georgetown UniversityWilliam B. Rouse is Research Professor in the McCourt School of Public Policy at Georgetown University and Professor Emeritus and former Chair of the School of Industrial and Systelc$