Transgenic and Knockout Models of Neuropsychiatric Disorders [Paperback]

In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, and speech disorders, as well as disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder.and Overview.- Transgenic and Knockout Models of Psychiatric Disorders.- Transgenic Mouse Models and Human Psychiatric Disease.- Transgenic and Knockout Mouse Models.- If Only They Could Talk.- Transgenic and Knockout Models of Neurocognitive Dysfunction.- Spinocerebellar Ataxia Type 1.- Mouse Models of Hereditary Mental Retardation.- How Can Studies of Animals Help to Uncover the Roles of Genes Implicated in Human Speech and Language Disorders?.- Animal Models of Autism.- Transgenic and Knockout Models of Neuropsychiatric Dysfunction.- Genetic Mouse Models of Psychiatric Disorders.- Animal Models of Psychosis.- Animal Models of Anxiety.- Modeling Human Anxiety and Depression in Mutant Mice.- Mutant Mouse Models of Bipolar Disorder.Neuroscientists are now establishing meaningful genotype-phenotype relationships for complex neurobehavioral and neuropsychiatric disorders and even creating animal models for these dysfunctions. These developments have made it imperative to know when such transgenic and knockout models are valid for the human disorders they represent. In Transgenic and Knockout Models of Neuropsychiatric Disorders, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from thelÃ3