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This volume is one of those published from the proceedings of the invited lectures to the First International Congress of Comparative Physiology and Biochemistry I organized at Liege (Belgium) in August 1984 under the auspices of the Section of Comparative Physiology and Biochemistry of the International Union of Biological Sciences. In a general foreword to these different volumes, it seems to me appropriate to consider briefly what may be the comparative approach. Living organisms, beyond the diversity of their morphological forms, have evolved a widespread range of basic solutions to cope with the different problems, both organismal and environmental with which they are faced. Soon after the turn of the century, some biologists realized that these solutions can be best comprehended in the frame? work of a comparative approach integrating results of physiological and biochemical studies done at the organismic, cellular and molecular levels. The development of this approach amongst both physiologists and biochemists remained, however, extremely slow until recently.Symposium I Regulation of Ion Transport Across Epithelial Membranes.- Neurohumoral Regulation of HCO3- Secretion by Choroid Plexus.- cAMP Increases the Apical Cl--Conductance in the Rectal Gland of Squalus acanthias.- Control of Chloride Secretion by Intracellular Calcium in the Rat Colon.- Passive Cl- Currents in Toad Skin: Potential Dependence and Relation to Mitochondria-Rich Cell Density.- Na+ Transport in Toad Bladder Microsomes.- Apical K+ Channels in Frog Skin: A Pathway for K+ Excretion.- Coupling of the Free Energy of Hydrolysis of ATP to Na+ Transport Across Frog Skin.- Symposium II Mineralocorticoid Control of Ion Transport Role in NaCl Adaptation.- Osmotic Control of Aldosterone Secretion.- Acute, Delayed, and Chronic Actions of Mineralocorticoids.- Evidence for Bipolar Effects of Aldosterone in Toad Skin.- Physiological Mechanisms Underlying the Stimulation of Na Transport in the Toad UrinalcÖ