The Treatment of Mycosis with Imidazole Derivatives [Paperback]

1 Introduction.- 1.1 Antimicrobial Therapy.- 1.2 Microbial Diseases of the Skin and Mucous Membranes.- 1.3 Antimicrobial Drugs for Local Application.- 2 Broad-Spectrum Antimicrobials for Local Application.- 2.1 Preliminary Remarks.- 2.2 Disinf ectants and Antiseptics.- 2.3 Antibiotics.- 2.4 Chemotherapeutic Agents.- 2.5 Imidazole Derivatives with Antimicrobial Action.- 2.5.1 General.- 2.5.2 Chlormidazole.- 2.5.3 Clotrimazole.- 2.5.4 Miconazole and Isoconazole.- 2.5.5 Econazole.- 2.5.6 Ketoconazole.- 2.5.7 Assessment of Imidazole Derivatives.- 3 Econazole.- 3.1 General.- 3.2 Chemical Structure.- 3.3 Physical Properties.- 3.4 Antimicrobial Spectrum.- 3.4.1 Antifungal Activity.- 3.4.2 Antibacterial Activity.- 3.4.3 Comparison of the Antimicrobial Activity of Econazole with Other Local Therapeutic Agents.- 3.4.4 Activity Against Protozoa (Trichomonads).- 4 General Microbiology of Imidazole Derivatives for Local Application.- 4.1 Preliminary Remarks.- 4.2 Modeof Action.- 4.2.1 Morphological Findings.- 4.2.2 Biochemical Effects.- 4.2.3 Sites of Action in the Cell.- 4.3 Resistance and Tolerance.- 4.4 Interactions with Other Compounds.- 4.4.1 Preliminary Remarks.- 4.4.2 Proteins.- 4.4.3 Lipids.- 4.4.4 Glucocorticoids.- 4.4.5 Antibacterial Substances.- 4.4.6 Antimycotic Substances.- 4.4.7 Antibacterial Substances and Glucocorticoids.- 4.4.8 Conclusions.- 4.5 Bioavailability Studies.- 5 Therapeutic Use of Imidazole Derivatives in Animals (Experimental Therapy).- 5.1 Local Application.- 5.2 Systemic Application.- 6 General Pharmacology of the Imidazole Derivatives in Man and Animals.- 6.1 Pharmacologic Properties (Apart from Antimicrobial Action) ...- 6.2 Absorption, Excretion, and Metabolism in Animals.- 6.2.1 Systemic Application.- 6.2.2 Local Application to the Skin and Mucous Membranes.- 6.3 Absorption, Excretion, and Metabolism in Man.- 6.3.1 Systemic Application.- 6.3.2 Local Application to the Outer Skin.- 6.3.3 Local Application to the Vaginal Epithelium.- 6.3.4 ConclulãM