Viral Cytopathology: Cellular Macromolecular Synthesis and Cytocidal Viruses Including a Cumulative Index to the Authors and Major Topics Covered in V [Paperback]

The time seems ripe for a critical compendium of that segment of the biological universe we call viruses. Virology, as a science, having passed only recently through its descriptive phase of naming and numbering, has probably reached that stage at which relatively few new-truly new-viruses will be discovered. Triggered by the intellectual probes and techniques of molecular biology, genetics, bio? chemical cytology, and high resolution microscopy and spectroscopy, the field has experienced a genuine information explosion. Few serious attempts have been made to chronicle these events. This comprehensive series, which will comprise some 6000 pages in a total of 19 volumes, represents a commitment by a large group of active investigators to analyze, digest, and expostulate on the great mass of data relating to viruses, much of which is now amorphous and disjointed, and scattered throughout a wide literature. In this way, we hope to place the entire field in perspective, and to develop an invaluable reference and sourcebook for researchers and students at all levels. This series is designed as a continuum that can be entered any? where, but which also provides a logical progression of developing facts and integrated concepts.1 Cytopathic Effects of Viruses: A General Survey.- 1. Defining the Problem.- 2. Historical Background.- 3. Viral Cytopathology: General Principles.- 4. Specific Cytopathic Viruses: An Overview.- 5. Some Subcellular Targets of Pathogenic Viruses.- 6. Summary.- 7. References.- 2 Transcription by RNA Polymerase II.- 1. Introduction.- 2. Polymerase II Control Regions: In Vivo.- 3. Polymerase II Promoters: In Vitro.- 4. RNA Polymerase II and Factors.- 5. Closing Comments.- 6. References.- 3 Regulation of Eukaryotic Translation.- 1. Introduction.- 2. The Rate-Limiting Step in Translation.- 3. Functional Domains in Messenger RNA.- 4. Initiation of Translation.- 5. Role of Initiation Factors in Binding of mRNA.- 6. Translational Control by mRNA Competition.lƒB