Xenotransplantation [Hardcover]

Xenotransplantation could have an impact on at least three aspects of medicine. The first is as a means of overcoming a severe shortage of human donor organs for the treatment of organ failure. The second aspect relates to the possibility that a xenogeneic organ would not be susceptible to infection by a human virus and thus the xenograft might resist injury caused by such viruses. The third and, as of yet, unexplored aspect relates to a means of delivering genes for therapeutic purposes thus overcoming some of the limitations of conventional gene therapy.     

Genetic Modification of Xenografts.- Public Health Risks  Patient vs. Society in an Emerging Field.- Cross-Species Infections.- Non-Human Primate Herpesviruses: Importance for Xenotransplantation.- Understanding Xenotransplantation Risks from Non-Human Primate Retroviruses.- Exogenous Porcine Viruses.- Swine Hepatitis E Virus: Cross-Species Infection and Risk in Xenotransplantation.- Molecular Cloning and Functional Characterization of Infectious PERVand Development of Diagnostic Tests.- XenotransplantationFederal Regulatory Considerations.