Acute Myelogenous Leukemia [Paperback]

This is a timely compilation of new concepts in the molecular pathogenesis and molecular therapy of acute myelogenous leukemia (AML). The focus is on selected critical molecular determinants of AML pathogenesis and pathophysiology and the exploitation of these factors by diverse therapeutic agents and modalities. There is an emphasis throughout on the bidirectional flow of knowledge between the clinical and laboratory arenas.

Acute Myelogenous Leukemia is a timely compilation of new concepts in the molecular pathogenesis and molecular therapy of acute myelogenous leukemia (AML). The focus is on selected critical molecular determinants of AML pathogenesis and pathophysiology and the exploitation of these factors by diverse therapeutic agents and modalities. Bringing together new concepts and findings in the basic and clinical science of AML, the book emphasizes the molecular basis for new therapies that stand to have the greatest potential impact on the clinical face of these diseases. The text provides insights into selected novel strategies currently and prospectively being developed, including interruption of specific signal transduction pathways, modulation of gene expression, attempts to reinstate differentiation, and immunomodulation. There is an emphasis throughout on the bidirectional flow of knowledge between the clinical and laboratory arenas, and both basic and clinical scientists will benefit from this translational text.

TABLE OF CONTENTSI. Overview of AML: Francis Giles, MD AndersonII. Molecular Foundations of AML Pathogenesis and PathophysiologyA. Transcriptional Control of Myeloid Differentiation and Transformation: Alan Friedman, Johns HopkinsB. Myelodysplasia-Related AML: Ghulam Mufti, King's College, London, EnglandC. Treatment-Related AML: Michelle LeBeau, University of ChicagoD. DNA Damage and Repair: David Steensma and Scott Kaufmann Mayo ClinicE. Apoptosis: Ruben Mesa and Scott Kaufmann, Mayo ClinicF. Drug Rlc™