A workshop was organised in order to achieve multi-discipli-nary review of the pathogenesis and management of acutefailure, particularly as it occurs and is managed inintensive therapy units. The book deals with the realitiesand practicalities of this important area of acute medicine.Each chapter is followed by a discussion, so that a concen-sus view is obtained from an international body of experts.A workshop was organised in order to achieve multi-discipli-nary review of the pathogenesis and management of acutefailure, particularly as it occurs and is managed inintensive therapy units. The book deals with the realitiesand practicalities of this important area of acute medicine.Each chapter is followed by a discussion, so that a concen-sus view is obtained from an international body of experts.Section I: Definitions and Epidemiology.- 1 Acute Renal Failure in the ITU: The Nephrologists View.- 2 Epidemiology of Acute Renal Failure in France Today.- 3 Acute Renal Failure and Sepsis: A Microbiologists View.- 4 Acute Renal Failure at a Crossroads.- 5 Acute Renal Failure in Old Age.- Section II: Some Aspects of Renal Physiology.- 6 Cortical and Juxtamedullary Glomerular Blood Flow After Temporary Ischaemia.- 7 Are Atrial Pressures Involved in the Regulation of Sodium and Water Balance? Studies in Conscious Animals.- Section III: Pathogenesis of Acute Renal Failure in the Intensive Therapy Unit.- 8 Endothelial and Mesangial Cell Dysfunction in Acute Renal Failure.- 9 Role of the Medulla in Acute Renal Failure.- 10 Ischaemic Acute Renal Failure in an Intact Animal Model.- 11 Eicosanoids and Acute Renal Failure.- 12 Disturbances in Renal Function Associated with Hepatic Dysfunction.- 13 A Review of Mediators and the Hepatorenal Syndrome.- 14 Drug-Induced Acute Renal Failure.- 15 Nature of Postischaemic Renal Injury Following Aortic or Cardiac Surgery.- 16 Acute Renal Failure in Sepsis.- Section Il“%