The book is addressed to statisticians working at the forefront of the statistical analysis of complex and high dimensional data and offers a wide variety of statistical models, computer intensive methods and applications: network inference from the analysis of high dimensional data; new developments for bootstrapping complex data; regression analysis for measuring the downsize reputational risk; statistical methods for research on the human genome dynamics; inference in non-euclidean settings and for shape data; Bayesian methods for reliability and the analysis of complex data; methodological issues in using administrative data for clinical and epidemiological research; regression models with differential regularization; geostatistical methods for mobility analysis through mobile phone data exploration. This volume is the result of a careful selection among the contributions presented at the conference S.Co.2013: Complex data modeling and computationally intensive methods for estimation and prediction held at the Politecnico di Milano, 2013. All the papers published here have been rigorously peer-reviewed.1 Antonino Abbruzzo, Angelo M. Mineo: Inferring networks from high-dimensional data with mixed variables.- 2 Federico Andreis, Fulvia Mecatti: Rounding Non-integer Weights in Bootstrapping Non-iid Samples: actual problem or harmless practice?.- 3 Marika Arena, Giovanni Azzone, Antonio Conte, Piercesare Secchi, Simone Vantini: Measuring downsize reputational risk in the Oil & Gas industry.- 4 Laura Azzimonti, Marzia A. Cremona, Andrea Ghiglietti, Francesca Ieva, Alessandra Menafoglio, Alessia Pini, Paolo Zanini: BARCAMP Technology Foresight and Statistics for the Future.- 5 Francesca Chiaromonte, Kateryna D. Makova: Using statistics to shed light on the dynamics of the human genome: A review.- 6 Nader Ebrahimi, Ehsan S. Soofi and Refik Soyer: Information Theory and Bayesian Reliability Analysis: Recent Advances.- 7 Stephan F. Huckemann: (Semi-) Intrinsic l