Advances in Hematopoietic Stem Cell Transplantation and Molecular Therapy [Paperback]

Blood stem cell transplantation has become an established therapeutic option in the treatment of malignant diseases. At the same time molecular therapeutic approaches (i.e. gene therapy) are promising alternatives to the classical treatment of cancer. The proceedings give an overview of the biology of hematopoietic progenitor cells, peripheral stem cell transplantation in patients with hematological malignancies, recent developments in molecular diagnosis and gene therapeutic concepts, and show that successful future developments require cooperative research connecting basic science with clinical application.Blood stem cell transplantation has become an established therapeutic option in the treatment of malignant diseases. At the same time molecular therapeutic approaches (i.e. gene therapy) are promising alternatives to the classical treatment of cancer. The proceedings give an overview of the biology of hematopoietic progenitor cells, peripheral stem cell transplantation in patients with hematological malignancies, recent developments in molecular diagnosis and gene therapeutic concepts, and show that successful future developments require cooperative research connecting basic science with clinical application.Mobilization and Selection of CD34+Cells.- Autologous Stem Cell Transplantation for Chronic Myeloid Leukemia.- Autologous Stem Cell Transplantation.- Peripheral Blood Progenitor Cell Transplantation.- Molecular Monitoring of Residual Disease.- Delineation of Genomic Regions in Chromosome Band 7q22 Commonly Deleted in Myeloid Leukemias.- Molecular Cytogenic Analysis of Low-Grade B-Cell Neoplasias: A Comparative Genomic Hybridization Study.- Applications of Gene Transfer in Hematologic Malignancy.- Dendritic Cells for Somatic Gene Therapy.- Construction of Immunogenetic Tumor Cell Surfaces by Somatic Gene Transfer.- Adeno-associated Virus Type 2 Vector for Transduction of Hematopoietic Cells.- Protection of Hematopoietic Stem Cells from Chemotherapy-Induced Tolã#