Advances in Mutagenesis Research [Paperback]

Applied genetic research, genetic toxicology and mutation research investigate the mutagenicity and cancerogenicity of chemicals and other agents. Permanent mutation in genes and chromosomes, can be induced by a plethora of agents, including ionizing and nonionizing radiations, chemicals, and viruses. Among the aspects discussed by Advances in Mutagenesis Research are (1) the understanding of the molecular mechanisms leading to mutations, and (2) the prevention of a thoughtless introduction of mutagenic agents into the environment.Applied genetic research, genetic toxicology and mutation research investigate the mutagenicity and cancerogenicity of chemicals and other agents. Permanent mutation in genes and chromosomes, can be induced by a plethora of agents, including ionizing and nonionizing radiations, chemicals, and viruses. Among the aspects discussed by Advances in Mutagenesis Research are (1) the understanding of the molecular mechanisms leading to mutations, and (2) the prevention of a thoughtless introduction of mutagenic agents into the environment.Rejoining of Radiation-Induced DNA Double-Strand Breaks in Yeast.- 1 Introduction.- 2 Measurement of DNA Double-Strand Breaks by the Neutral Sucrose Sedimentation Method.- 3 Induction of DNA Double-Strand Breaks in Yeast Irradiated with Ionizing Radiations: Effect of Linear Energy Transfer and Oxia.- 4 DNA Double-Strand Breaks as Critical Lesions for Yeast Cell Killing.- 5 Rejoining of DNA Double-Strand Breaks Induced in Yeast by Sparsely Ionizing Radiation.- 6 Rejoining of DNA Double-Strand Breaks Induced in Yeast by 3.5 MeV ?-Particles.- 7 DNA-Double-Strand Breaks Induced in Anoxic Yeast Show Different Rejoining Kinetics Compared to Oxically Induced Double-Strand Breaks.- 8 Concluding Remarks.- References.- Cellular and Molecular Effects of Radon and Other Alpha Particle Emitters.- 1 Inhalation of Radon Induces Lung Cancer.- 2 Energy lÕ