First published in 2005, this book introduces the concept of allostasis and places it within the context of traditional homeostatic regulation.The concept of homeostasis is well established in medicine and physiology. In contrast, allostasis is a relatively new idea of 'viability through change'. This book, the first edited volume to focus on allostasis, orients the reader by addressing basic physiological regulatory systems, and examining bodily regulation under duress. It integrates the basic concepts of physiological homeostasis with disorders such as depression, stress, anxiety and addiction. It will appeal to graduate students, medical students, and researchers working in physiology, epidemiology, endocrinology, neuroendocrinology, neuroscience, and psychology.The concept of homeostasis is well established in medicine and physiology. In contrast, allostasis is a relatively new idea of 'viability through change'. This book, the first edited volume to focus on allostasis, orients the reader by addressing basic physiological regulatory systems, and examining bodily regulation under duress. It integrates the basic concepts of physiological homeostasis with disorders such as depression, stress, anxiety and addiction. It will appeal to graduate students, medical students, and researchers working in physiology, epidemiology, endocrinology, neuroendocrinology, neuroscience, and psychology.In contrast to homeostasis, allostasis refers to the relatively new idea of viability through change. This book addresses basic physiological regulatory systems, and examines bodily regulation under duress. It integrates the basic concepts of physiological homeostasis with disorders such as depression, stress, anxiety and addiction. It will interest graduate students, medical students, and researchers in physiology, epidemiology, endocrinology, neuroendocrinology, neuroscience, and psychology.1. Principles of allostasis: optimal design, predictive regulation, pathophysiology and ratlC