Amino Acid Neurotransmitters [Paperback]

1 Biochemical Pharmacology of GABA in CNS.- 1. Introduction.- 2. Effects of Compounds on the Metabolism of GABA in Vivo.- 2.1. Systemic Administration.- 2.2. Intracranial and Topical Application.- 3. Effects of Compounds on the Uptake and Release of GABA in Nervous Tissue.- 3.1. Uptake Studies.- 3.2. Release Studies.- 4. Effects of Compounds on the Interaction of GABA with Its Postsynaptic Receptor.- 5. Convulsant and Anticonvulsant Compounds Related to the GABA-Dependent Inhibitory Mechanism.- 5.1. Mechanisms of Drug-Induced Convulsions.- 5.2. Mechanisms of the Anticonvulsant Action of Drugs.- 6. Pharmacological Relationships Between Biogenic Amines and GABA.- 7. Effects of Compounds on GABA Metabolism During Ontogeny.- 8. Pharmacological Effects of GABA.- 9. Clinical Implications of Pharmacological Studies of GABA-Dependent Inhibition.- 10. References.- 2 Biochemistry of Glycine, Taurine, Glutamate, and Aspartate.- 1. Introduction.- 2. Chemistry.- 3. Occurrence.- 3.1. Assay Methods.- 3.2. Regional Distribution.- 3.3. Subcellular Distribution.- 4. Metabolism.- 4.1. Glycine.- 4.2. Taurine.- 4.3. Glutamate and Aspartate.- 5. Transport.- 5.1. Uptake.- 5.2. Release.- 6. Conclusion.- 7. References.- 3 Amino Acid Receptors in CNS. I. GABA and Glycine in Spinal Cord.- 1. Introduction.- 2. Localization of Glycine and GABA in Spinal Cord.- 2.1. Localization in Gray and White Matter.- 2.2. Effect of Destruction of Interneurons.- 2.3. Cellular Localization from Uptake and Autoradiographic Studies.- 3. Release of GABA and Glycine.- 4. Pharmacology of Agonists.- 4.1. Effects on Reflex Activity.- 4.2. Postsynaptic Effects on Single Cells.- 4.3. Effects on Presynaptic Terminals.- 4.4. Effects on Dorsal Root Ganglia.- 5. Pharmacology of Antagonists.- 5.1. Strychnine.- 5.2. Bicuculline and Picrotoxin.- 6. Miscellaneous Agents.- 7. Amino Acids in Supraspinal Regions.- 7.1. Cuneate Nucleus.- 7.2. Reticular Formation.- 8. Concluding Remarks.- 9. References.- 4 Amino Acid Receptors in lƒX