Analysis of Pharmaceuticals by Capillary Electrophoresis [Paperback]

Dieser erste Titel einer ganzen Serie von anwendungsbezogenen Handb?chern zur Kapillarelektrophorese besch?ftigt sich mit der Analytik von pharmazeutischen Substanzen. Dabei werden verschiedene Techniken praxisnah erl?utert. Jeder, der im Labor - ob wissenschaftlich oder praxisnah - mit der Analyse von oft chiralen Pharmazeutika konfrontiert ist, wird viele Hinweise und Tips f?r seine Arbeit finden.USP: Einzige Monographie zur Analyse von Pharmazeutika mit CE

This book describes the current state of the art for the analysis of pharmaceuticals by capillary electrophoresis and contains several hundred references to specific applications and methods. The main purpose of the book is to present the application possibilities of CE an therefore tabulated application data are provided.
Chapters of the book are devoted to providing details of individual application areas such as chiral analysis, determination of drug related impurities, determination of drug counter-ions, drug residue monitoring and main component assay. An introductory chapter provides theoretical background to CE an related techniques. A chapter is dedicated to capillary electrochromatography which highlights the importance this technique currently possesses. Successful regulatory acceptance of CE methods is also described. A comprehensive chapter covers method validation aspects. Other chapters include discrete areas such as the use of non-aqueous solvents, forensic applications of CE, the application of experimental designs, determination of drugs in biofluids, and the analysis of vitamins by CE.During the 1980's the analysis of pharmaceuticals was dominated by the use of High Perfor? mance Liquid Chromatography (HPLC). Other separative techniques such as Gas Chromato? graphy and Thin Layer Chromatography offered alternatives but their quantitative capabili? ties and/or solute range could not approach that of HPLC. The majority of pharmaceuticals are ionic and it would be reaslS[