Antibody-Drug Conjugates [Paperback]

Antibody-drug conjugates (ADCs) represent a promising therapeutic approach for cancer patients by combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic potency of chemotherapeutic drugs.? In Antibody-Drug Conjugates, expert researchers provide detailed protocols for many of the key ADC techniques necessary for working in the field. These chapters and methodologies are aimed at the key tasks necessary to identify a suitable target, properly design the mAb, the linker and the payload, as well as to conjugate them in a reproducible and scalable fashion.? Written in the highly successful Methods in Molecular Biology format, these detailed chapters include the kind of practical implementation advice that guarantees quality results.

?

Authoritative and timely, Antibody-Drug Conjugates aims to further drive ADC development and thus help toward improving cancer treatments of the future.This book presents detailed protocols for key antibody-drug conjugates techniques necessary for working in the field. It provides step-by-step methodologies that are readily reproducible and features expert tips and key implementation advice.

1. Antibody-Drug Conjugate (ADC) Clinical Pipeline: A Review

??????????? Ingrid Sassoon and V?ronique Blanc

?

2. Antibody-Drug Conjugate Target Selection: Critical Factors

??????????? Neil H. Bander

?

3. Selecting an Optimal Antibody for Antibody-Drug Conjugate Therapy: Internalization and Intracellular Localization

??????????? Jay Harper, Shenlan Mao, Patrick Strout, and Adeela Kamal

?

4. Antibody-Drug Conjugate Payloads

??????????? Jan Anderl, Heinz Faulstich, Torsten Hechler and Michael Kulke

?

5. Llã!