Antihypertensive Drugs Today [Paperback]

of Volume 4.- I Antihypertensive Drugs: Clinical Pharmacology and Therapeutic Use.- 1. Diuretics.- 1.1 Mechanism of Action.- 1.2 Pharmacokinetics.- 1.3 Clinical Use.- 1.4 Side Effects.- 2. Sympathetic Inhibiting Agents.- 2.1 Ganglion Blocking Agents.- 2.2 Guanethidine and Other Adrenergic Neurone Blocking Drugs.- 2.3 Rauwolfia Alkaloids.- 2.4 Methyldopa.- 2.5 Clonidine.- 2.6 Prazosin.- 2.7 ?-Adrenoceptor Blocking Agents.- 2.8 Labetalol.- 2.9 MAO Inhibitors.- 3. Direct-acting Vasodilators.- 3.1 Hydrallazine.- 3.2 Minoxidil.- 3.3 Diazoxide.- 3.4 Sodium Nitroprusside.- 4. Angiotensin II Analogues and Converting Enzyme Inhibitors.- 5. Treatment Regimens.- 5.1 Mild Hypertension.- 5.2 Moderate to Severe Hypertension.- 5.3 Resistant Hypertension.- 5.4 Hypertensive Emergencies and Presence of Complications.- II Metoprolol: A Review of its Pharmacological Properties and Therapeutic Efficacy in Hypertension.- 1. Animal Pharmacodynamic Studies.- 1.1 ?-Adrenoceptor Blocking Effect.- 1.2 Partial Agonist Activity.- 1.3 ?-Adrenoceptor Selectivity.- 1.4 Antihypertensive Effect.- 1.5 Cardiovascular Haemodynamics in Dogs.- 1.6 Toxicology Studies.- 1.7 Dysmotphology and Reproduction Studies.- 2. Animal Pharmacokinetic Studies.- 2.1 Absorption.- 2.2 Half-Life.- 2.3 Distribution.- 2.4 Metabolism.- 3. Human Pharmacodynamic Studies.- 3.1 Effect on Heart Rate and Cardiac Output.- 3.2 Effect on Blood Pressure.- 3.3 ?-Adrenoceptor Selectivity.- 3.4 Effect on Plasma Renin Activity.- 3.5 Metabolic Effects.- 4. Pharmacokinetic Studies in Man.- 4.1 Absorption.- 4.2 Distribution.- 4.3 Metabolism and Excretion.- 4.4 Plasma Concentration and Clinical Effects.- 5. Therapeutic Trials.- 5.1 Comparison with Placebo.- 5.2 Comparison with Other Drugs.- 5.3 Metoprolol Combined with Other Drugs.- 5.4 Long-term Treatment of Hypertension.- 5.5 Is the Efficacy of Metoprolol in Hypertension Influenced by Frequency of Administration?.- 5.6 What is the Role of Metoprolol in Hypertension?.- 6. Side Effects.- 7. Cls4