Anti-Inflammatory Drugs [Paperback]

With contributions by numerous expertsScreening and Toxicity of Anti-Inflammatory Drugs.- 19 Screening and Assessment of the Potency of Anti-Inflammatory Drugs in vitro.- A. Introduction.- B. Interaction With Non-Enzymic Proteins.- I. Binding to Plasma Proteins.- 1. Displacement Reactions.- 2. Disulphide Interchange Reactions.- 3. Protection Against Protein Denaturation.- 4. Fibrinolytic Activity.- II. Interaction With Biological Membranes.- 1. Effects on Erythrocyte Membrane.- 2. Effects on Lysosomal Membrane.- 3. Cytotoxic Properties.- 4. Effects on Leucocyte Migration.- C. Interaction With Enzymic Proteins.- I. General Considerations.- II. Interaction With Enzymes Involved in Carbohydrate, Protein, and Nucleic Acid Metabolism.- 1. Carbohydrate, Protein, and Amino Acid Metabolism.- 2. Nucleic Acid and Nucleotide Metabolism.- III. Inhibition of Prostaglandin Synthetase.- 1. Prostaglandin Synthetase System.- 2. Assay of Prostaglandin Synthetase Activity.- 3. Prostaglandin Synthetase Inhibitors.- 4. Inhibition of Platelet Aggregation.- 5. Effects on Smooth Muscle.- D. Conclusions.- References.- 20 Inhibition of Erythema and Local Hyperthermia.- A. Introduction.- B. Ultraviolet (UV) Light and the Erythematous Response.- C. Instrumentation.- I. Light Sources for Induction of Erythema.- II. Measurement of Erythema and Local Hyperthermia.- 1. Erythema.- 2. Skin Temperature.- D. Procedures.- I. Erythema.- 1. UV-Induced.- 2. Thurfyl Nicotinate-Induced.- 3. Miscellaneous Procedures for Producing Erythema.- II. Local Hyperthermia.- 1. Local Hyperthermia in Paws of Rats Injected With Irritants.- 2. Local Hyperthermia in UV-Irradiated Skin.- E. Inhibition of Erythema and Local Hyperthermia.- I. UV-Induced Erythema.- 1. Systemic Administration of Drugs.- 2. Topically or Intradermally.- II. Tetrahydrofurfuryl Nicotinate (THFN) Erythema.- III. Other Erythemas.- IV. Local Hyperthermia.- F. Conclusion.- References.- 21 Oedema and Increased Vascular Permeability.- A. General Principl3&