Antisense Therapeutics [Paperback]

A timely primer on the new reality of antisense and RNA inhibition for treating a broad range of diseases. The authors show how antisense oligonucleotides are being designed and studied in relation to hypertension, various cancers, inflammatory bowel disease, brain disorders, the blood-brain barrier, and drug delivery. Highlights include RNA-based therapies for many diseases, up-to-date methods and applications, and insight into the enormous potential to provide a new generation of drugs.A timely primer on the new reality of antisense and RNA inhibition for treating a broad range of diseases. The authors show how antisense oligonucleotides are being designed and studied in relation to hypertension, various cancers, inflammatory bowel disease, brain disorders, the blood-brain barrier, and drug delivery. Highlights include RNA-based therapies for many diseases, up-to-date methods and applications, and insight into the enormous potential to provide a new generation of drugs.Part I. IntroductionAntisense Therapeutics: A Promise Waiting to be FulfilledM. Ian PhillipsAntisense Inhibition: Oligonucleotides, Ribozymes, and siRNAsY. Clare Zhang, Meghan M. Taylor, Willis K. Samson, and M. Ian PhillipsPart II. CardiovascularLocal Application of Antisense for Prevention of RestenosisPatrick L. Iversen, Nicholas Kipshidze, Jeffrey W. Moses, and Martin B. LeonAntisense Therapeutics for Hypertension: Targeting the Renin-Angiotensin SystemM. Ian Phillips and Birgitta KimuraAntisense Strategies for the Treatment of Heart FailureSian E. Harding, Federica del Monte, and Roger J. HajjarPart III. CancerClinical Studies of Antisense Oligonucleotides for Cancer TherapyRosanne M. Orr and F. Andrew DorrAntisense Therapy in Clinical Oncology: Preclinical and Clinical ExperiencesIngo TammRadionuclide-Peptide Nucleic Acid Diagnosis and Treatment of Pancreatic CancerEric Wickstrom, Xiaobing Tian, Nariman V. Amirkhanov, Atis Chakrabarti, Mohan R. Aruva, Ponugoti S. Rao, Wenyi Qin, Weizhu Zhu, l#Ý