APC Proteins [Paperback]

The Apc protein is a multifunctional participant in a diverse array of cellular functions. This book provides an overview of the functions performed by the Apc protein.

1. APC and ?-Catenin DegradationJennifer Kennell and Kenneth M. Cadigan 2. Nuclear APCKristi L. Neufeld 3. APC in Cell MigrationSandrine Etienne-Manneville 4. The APC-EB1 InteractionEwan E. Morrison 5. The Role of APC in Mitosis and in Chromosome InstabilityChristine M. Caldwell and Kenneth B. Kaplan 6. Role of APC and its Binding Partners in Regulating Microtubules in MitosisShirin Bahmanyar, W. James Nelson and Angela I.M. Barth 7. The Adenomatous Polyposis Coli Tumor Suppressor and Wnt Signaling in the Regulation of ApoptosisHassina Benchabane and Yashi Ahmed 8. APC and Its Modifiers in Colon CancerLawrence N. Kwong and William F. Dove 9. Tissue-Specific Tumour Suppression by APCOwen Sansom 10. Extra-Colonic Manifestations of Familial Adenomatous Polyposis ColiAlison H. Trainer

Inke N?thke is the professor of Epithelial Biology at the University of Dundee. Her research interest is to determine how specific molecular changes produce changes in cells and ultimately in whole tissues during early stages of tumourigenesis. Her focus is on colorectal cancers but the common epithelial origin of most tumours makes this work relevant to many other organs. Her work has led her to examine not only how cells move and divide but also how they know where they are, and how they work together to build a functional tissue. Professor N?thke received her training at San Jose State University, the University of California San Francisco, Stanford and Harvard Medical Schools.

Brooke McCartney is an Assistant Professor of Biological Sciences at Carnegie Mellon University. She is interested in how signaling pathways regulate the cytoskeleton and how this leads to changes in cytoskeletal and tissue architecture. The focusl�