Application of Hyperthermia in the Treatment of Cancer [Paperback]

Physicians, biologists and physicists present their recent work in the field of hyperthermia with regard to both its application and its combination with radiation and chemotherapy. Current technical possibilities, clinical management and major aspects of its use for superficial and deep-seated tumors are pointed out. The main topics discussed are: changes of metabolism and microcirculation under heat conditions, the biological interaction of heat with X-rays and several chemotherapeutic agents, and the most recent clinical data from different institutions on the combined application in the treatment of cancer.Physicians, biologists and physicists present their recent work in the field of hyperthermia with regard to both its application and its combination with radiation and chemotherapy. Current technical possibilities, clinical management and major aspects of its use for superficial and deep-seated tumors are pointed out. The main topics discussed are: changes of metabolism and microcirculation under heat conditions, the biological interaction of heat with X-rays and several chemotherapeutic agents, and the most recent clinical data from different institutions on the combined application in the treatment of cancer.Biological, Biophysical and Technical Concepts of Hyperthermia.- The Concept of Thermal Dose.- Aspects of Metabolic Change After Hyperthermia.- Hyaluronic Acid Degradation Mediated by Thiols and Effects of Hyperthermic Conditions.- Glutathione Level in Melanoma Cells and Tissue.- Changes of Plasma Acetate Levels in Whole-Body Hyperthermia.- Physiological Effects of Hyperthermia.- Hyperthermia-Induced Changes in Tumor Microcirculation.- Changes in Tumor Vasculature Under Fractionated Radiation -Hyperthermia Treatment.- Pathophysiology of Tumors in Hyperthermia.- Technical Aspects of Hyperthermia.- Advanced Technique in Localized Current Field Hyperthermia.- A 500-kHz Localized Current Field Hyperthermia System for Use with Ophthalmic Plaque Radiotherapy.-ls�