Auto-immunity in the Endocrine System [Paperback]

1 General Principles of Immunology (as Related to Auto-immune Disease).- 1.1 Immunity and the Immune Response.- 1.1.1 The Role of Lymphocytes in the Immune Response.- 1.1.2 Types of Lymphocytes.- 1.1.3 Processing of Antigen.- 1.1.4 Genetic Control of the Immune Response.- 1.1.5 Significance of HLA Disease Associations.- 1.1.6 Cell Interactions and Immunoregulation.- 1.2 References.- 2 Auto-immunity in Thyroid Disease.- 2.1 Introduction.- 2.2 Studies of the Immunological Aspects of Thyroid Disease.- 2.2.1 Initial Observations.- 2.2.2 Experimental and Spontaneous Animal Models in Auto-immune Thyroid Disease.- 2.2.2.1 Experimental Auto-immune Thyroiditis.- 2.2.2.2 Spontaneous Auto-immune Thyroiditis in Animals.- 2.2.2.3 Attempts to Produce Experimental Models for Graves Disease.- 2.2.3 Humoral Immunity in Human Thyroid Disease.- 2.2.3.1 Thyroglobulin Antibodies.- 2.2.3.2 Antimicrosomal Antibodies.- 2.2.3.3 Antibody to a Colloid Component Other than Thyroglobulin.- 2.2.3.4 Antibodies to the Thyroid Hormones.- 2.2.3.5 Thyrotrophin (TSH) Receptor-Related Antigen and Cell Surface Antigens and Their Relationship to Thyroid-Stimulating Immunoglobulin.- 2.2.3.6 Immune Complexes, Rheumatoid Factors and Other Antibodies.- 2.2.3.7 Production of Thyroid Antibodies and Thyroid-Stimulating Immunoglobulin In Vitro.- 2.2.4 Cellular Aspects of Graves and Hashimotos Diseases.- 2.2.4.1 Thyroid Lymphocytes.- 2.2.4.2 Peripheral Blood Lymphocytes.- 2.2.4.3 Cytotoxic Lymphocytes.- 2.2.4.4 Migration Inhibition Factor Procedures.- 2.2.4.5 Evidence for a Defect in Suppressor T-lymphocytes.- 2.2.4.6 Other Cellular Mechanisms.- 2.2.5 The Role of the Antigen: Is There Antigenic Stimulation?.- 2.2.6 The Genetics of Graves and Hashimotos Diseases.- 2.2.6.1 Observations in Twins.- 2.2.6.2 Age-specific Incidence Rates in Graves and Hashimotos Diseases.- 2.2.6.3 Thyroid Auto-antibodies and Chromosomal Abnormalities.- 2.2.6.4 HLA Associations.- 2.2.6.5 Studies of Relatives of Patients with GravelÃ^