Bacterial Therapy of Cancer Methods and Protocols [Paperback]

This volumeexplores the evolution of bacterial cancer therapy and describes the moderntechniques used in therapy today. The chapters in this book cover a broad rangeof topics such as the development of tumor-targeting Salmonella typhimurium A1-R, a microfluidic device for precise quantification of the interactions betweentumor-targeting bacteria and tumor tissue, non-invasive in vivo imaging ofbacteria-mediated cancer therapy using bio-luminescent bacteria, methods toachieve remote-control of therapeutic gene expression in tumor-targetingbacteria, and cell-cycle decoy of cancer cells resistant to cytotoxic drugs todrug sensitivity by S. typhimurium A1-R. This book concludes witha chapter on the future potential of bacterial therapy of cancer. Written inthe highly successful Methods in Molecular Biology series format,chapters include introductions to their respective topics, lists of thenecessary materials and reagents, step-by-step, readily reproducible laboratoryprotocols, and tips on troubleshooting and avoiding known pitfalls.

Thoroughand informative, Bacterial Therapy of Cancer: Methods and Protocols isa valuable resource for anyone who is interested in cancer and bacterialtherapy.

1.      Tumor Targeting Salmonella Typhimurium A1-R: An Overview
Robert M. Hoffman

2.      Enhancement of Tumor-Targeted Delivery ofBacteria with Nitroglycerin Involving Augmentation of the ERP Effect
Jun Fang, Lio Long, and Hiroshi Maeda

3.      Oral Delivery of Tumor-Targeting Salmonella to Treat Cancer in Mice
Dongping Wei and Lijun Jia
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