Bile Acids: Toxicology and Bioactivity [Hardcover]

This book is the first book to comprehensively cover the important properties of bile acids and bile acid toxicology. Bile acids are increasingly being seen as important carcinogenic agents in cancers and there is wide recognition of their role in obesity linked diseases. Topics covered in this book include: synthesis and chemistry, regulation and biotransformation in vivo; Bile acid induced cell death; Genotoxicity; Bile acid induced gene expression and cell signalling abnormalities and liver disease; colorectal cancer, oesophageal cancer and obesity. This book will appeal to all researchers and students who wish to understand the basic toxicology and bioactivity of Bile acids. One can only admire the efforts of the editors, who managed to include so many subjects in just over 150 pages, each covered in a short concise text, with each chapter ending with a succinct summary of the main ideas of the chapter, of great help when one wishes to just see the main ideas on one topic such as the way in which bile acids promote carcinogenesis in general, or in a specific part of the gastrointestinal tract. One can recommend Bile Acids: Toxicology and Bioactivity to everyone who wishes to gain new insights into this field, not only because it represents, even now, one of the few texts available, but also (and mainly) due to its great quality of covering the field in a concise but comprehensive manner. The price might still look steep, but it is clearly worth every penny. Bile acid synthesis; regulation and chemistry; Bile acid physiology and measurement; Bile acids and apoptosis; Bile acid induced Genotoxicity; Bile acids and colorectal cancer; Bile acids and oesophageal cancer Bile acids and obesity Bile acids and cholesterol gallstone formationBile acids are increasingly being seen as extremely important carcinogenic agents in cancers of the bile duct, liver, colon, rectum, and oesophagus. In recent years there have been tremendous advances in the understanding of the mechl³e