The Biogenesis of Cellular Organelles [Paperback]

The Biogenesis of Cellular Organelles represents a comprehensive summary of recent advances in the study of the biogenesis and functional dynamics of the major organelles operating in the eukaryotic cell. This book begins by placing the study of organelle biogenesis in a historical perspective by describing past scientific strategies, theories, and findings and relating these foundations to current investigations. Reviews of protein and lipid mediators important for organelle biogenesis are then presented, and are followed by summaries focused on the endoplasmic reticulum, Golgi, lysosome, nucleus, mitochondria, and peroxisome.

 

Preface 1. Theory of Organelle Biogenesis: A Historical Perspective; Barbara M. Mullock and J. Paul Luzio.- Definitions.- The History of Organelle Recognition.- Protein Synthesis and Targeting.- Organization into Complex Structures.- Organelle Inheritance.-Challenges.- 2. Protein Coats As Mediators of Intracellular Sorting and Organelle Biogenesis; Chris Mullins.- Clathrin: A Scaffold for Protein Coats.- Adaptor Protein Complexes: Adaptors for Coats of the Late-Secretory and Endocytic Pathways.- COP Complexes: Protein Coats of the Early Secretory Pathway.- Adaptor-Related Proteins Define Novel Coats of the Secretory and Endocytic Pathways.- 3. The Role of Proteins and Lipids in Organelle Biogenesis in the Secretory Pathway; Thomas F. J. Martin.- Protein Sorting Confers a Transient Nature to Secretory Pathway Organelles.- The Molecular Machinery Regulating Compartment Identity.- General Mechanisms Employed for Cargo Exit and Entry: Fission and Fusion.- Exit Mechanisms in Trafficking.- Entry Mechanisms in Trafficking: Tethering, Priming and Fusion.- 4. Endoplasmic Reticulum Biogenesis: Proliferation and Differentiation; Erik Snapp.- ER Functions.- Building Blocks of the ER.- ER Biogenesis.- ER Network Formation.- ER Subdomains.- ER Differentiation.- Putting It All Togel£*