Bioinformatics and Drug Discovery [Paperback]

A collection of readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and in silico protein design, and cheminformatics, in a variety of practical situations. Because these technologies are still emergent, each chapter contains an extended introduction that explains the theory and application of the technology and techniques described.A collection of readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and in silico protein design, and cheminformatics, in a variety of practical situations. Because these technologies are still emergent, each chapter contains an extended introduction that explains the theory and application of the technology and techniques described.New Strategies in Drug DiscoveryEliot H. Ohlstein, Anthony G. Johnson, John D. Elliot, and Anne M. RomanicBasic Microarray Analysis: Strategies for Successful ExperimentsScott A. NessFrom Microarray to Biological Networks: Analysis of Gene Expression ProfilesXiwei Wu and T. Gregory DeweyMicroarray Analysis in Drug Discovery and Clinical ApplicationsSiqun Wang and Qiong ChengOntology-Driven Approaches to Analyzing Data in Functional GenomicsFrancisco Azuaje, Fatima Al-Shahrour, and Joaquin DopazoGene Evolution and Drug DiscoveryJames O. McInerney, Caroline S. Finnerty, Jennifer M. Commins, and Gayle K. PhilipStandardization of Microarray and Pharmacogenomics DataCasey S. Husser, Jeffrey R. Buchhalter, O. Scott Raffo, Amnon Shabo, Steven H. Brown, Karen E. Lee, and Peter L. ElkinClinical ApplS'