Bispecific Antibodies [Paperback]

The concept of using bispecific antibodies for cancer therapy by retargeting immune effector cells was developed several years ago. Initial clinical studies were rather disappointing mainly due to low efficacy, severe side effects and the immunogenicity of the bispecific antibodies. The progress in antibody engineering finally led to the generation of new classes of bispecific antibodies lacking these obstacles. In addition, new applications were established, such as pre-targeting strategies in radioimmunotherapy and dual targeting approaches in order to improve binding, selectivity and efficacy.

In this book, the different ways of generating bispecific antibodies are described, with emphasis on recombinant formats. The various applications of bispecific antibodies, e.g. in cellular cancer immunotherapy, radioimmunotherapy and pretargeting strategies are covered, and emerging applications such as dual targeting strategies, which involve the simultaneous inhibition of two targets, are addressed.

Janice M. Reichert: Foreword.- Roland Kontermann: Bispecific antibodies: developments and current perspectives.- Gerd Moldenhauer: Bispecific antibodies from hybrid hybridoma.- Diego Ellerman & Justin Scheer: Generation of bispecific antibodies by chemical conjugation.- Christoph Stein, Ingo Schubert & Georg Fey: Trivalent and trispecific antibody derivatives for cancer therapy.- Dafne M?ller & Roland Kontermann: Diabodies, single-chain diabodies and their derivatives.- Patrick Chames & Daniel Baty: Bispecific single domain antibodies.- John L?fblom & Fredrik Y. Frejd: Alternative scaffolds as bispecific antibody mimetics.- Nico Mertens: Tribodies: buil£‘