Bone Metastasis and Molecular Mechanisms Pathophysiology [Hardcover]

Patients with advanced breast or prostate cancers usually develop bone metastases. The principal complications resulting from metastatic bone disease are pain, spinal cord compression, pathologic fractures and bone marrow suppression. Improving the management of bone metastases is crucial to quality of life for patients with breast and prostate cancer.

Advances in understanding of the molecular mechanisms underlying the pathophysiology of bone metastasis are driving the development of new therapeutic strategies.

Patients with advanced breast or prostate cancers usually develop bone metastases. The principal complications resulting from metastatic bone disease are pain, spinal cord compression, pathologic fractures and bone marrow suppression. Improving the management of bone metastases is crucial to quality of life for patients with breast and prostate cancer.

Advances in understanding of the molecular mechanisms underlying the pathophysiology of bone metastasis are driving the development of new therapeutic strategies.

List of ContributorsPreface; Gurmit Singh1 Models of Breast Cancer Metastasis to Bone: Characterization of a Clinically Relevant Model; Belinda S. Parker, Bederich L. Eckhardt and Robin L. Anderson2 Quantitation of Bone Metastasis in Experimental Systems; Julie A. Sharp and Erik W. Thompson3 Comparative Morphometric Study on Bone Remodeling in Human Specimens and in Experimental Models of Metastatic Bone Disease; Snezana Vukmirovic-Popovic, Eric Seidlitz, F. William Orr and Gurmit Singh4 Clinical Modalities for the Diagnosis, Characterization and Detection of Bone Metastases; Michael H. Weber, Jonathan C. Sharp, Thomas H. Hassard,Martin Reed, James A. Thliveris and F. William Orr5 Metastasis in the Bone Marrow Microenviroment; Paolo Bianco, Mara Riminucci and Pamela Gehron Robey6 The Role of Tumor-Associated Macrophages in Metastasis-Associated Osteolysis; Nicholas. A. Athanalãž