Brain Damage and Repair From Molecular Research to Clinical Therapy [Hardcover]

This book builds a novel bridge from molecular research to clinical therapy. This approach reveals the functional features of neurons and glia in the particular context of vulnerability and self-protection, intracellular properties and extracellular matrix. Arising from this platform, this volume unfolds the molecular and systemic processes underlying migration disorders, axonal injury, repair and regeneration.

Accompanying Words. Preface. Members of the Management Committee.

A: The Vulnerable Neuron or Why Neurons Die. 1. The aging brain - the burden of life; S. Hoyer, K. Plaschke. 2. Gene expression and its regulation in neurons; L. Kaczmarek. 3. Morphological peculiarities of the neuron; I.P. Johnson. 4. Synaptic plasticity: hyperexcitability and synaptic silencing; L. Mart?nez-Mill?n, G. Garc?a del Ca?o, I. Gerrikagoitia. 5. The axonal burden; H. Aldskogius. 6. The self-destruction of neurons - physiological and pathophysiological decisions for the functional integrity; J. Prehn, D. K?gel. 7. The organelles I: Mitochondrial failure; J.M. Cuezva. 8. The organelles II: Endoplasmic reticulum and its overload; W. Paschen. 9. Transcriptional dysfunctions as pathogenic mechanism of neurodegenerative diseases; B. Kaminski. 10. Formation of radicals; M. G?tz, M. Gerlach.

B: The Extraneuronal Matrix - Sites of Multiple Degenerative Processes. 11. Axon guidance and repulsion. The molecular code of social life in the brain; J.A. del R?o, F. de Castro, E. Soriano. 12. Microglia and the cerebral defence system; D. van Rossum, U.K. Hanisch. 13. Generation and differentiation of astrocytes during central nervous system development and injury; C. Vicario-Abej?n, M.J. Yusta-Boyo. 14. Oligodendrocytes in health and disease; C. Domercq, C. Matute. 15. The myelin glial cell of the peripheral nervous system: The Schwann cell; D. Echevarr?a, S. Martinez. 16. The M?ller glia: role in neuroprotection; E. Vecino, M. Garc?al¢