Cancer Drug Resistance Overviews and Methods [Hardcover]

This volume discusses the latest advancements and technologies used in cancer drug resistance research. Cancer Drug Resistance: Overviews and Methods?contains chapters that cover topics such as: studying the mechanics of resistance to DNA damaging therapeutic drugs; studies to delineate the role of efflux transporters; expression of drug transporters; resistance to targeted therapies in breast cancer; the role of microRNAs in current pancreatic cancer treatment; and cancer exosomes as mediators of drug resistance or clinical and molecular methods in drug development and the use of bioinformatics in the management of cancer drug resistance data. Written in the highly successful?Methods in Molecular Biology series format, chapters include overviews of the main issues in cancer drug resistance and the respective mechanisms, as well as introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Cancer Drug Resistance: Overviews and Methods, is a valuable resource to researchers, oncobiologists and clinical oncologists or anyone else who is interested in the study of cancer and its drug resistances.

1. Cancer Drug Resistance: A Brief Overview from a Genetic Viewpoint?
Jos? Rueff and Ant?nio S. Rodrigues

2. Classical and Targeted Anti-Cancer Drugs: An Appraisal of Mechanisms of Multidrug Resistance
Bruce C. Baguley

3. In Vitro Methods for Studying the Mechanisms of Resistance to DNA Damaging Therapeutic Drugs
Pasal³"