Capsaicin as a Therapeutic Molecule [Hardcover]

This volume provides an up-to-date account of the achievements pertaining to the application of capsaicin and capsaicin-like molecules in the therapy of various human ailments such as pain, non-allergic rhinitis, obesity, tumors and gastrointestinal, dermatologic and urologic disorders. It discusses the basic functions?of the capsaicin receptor (TRPV1), its mechanisms of action and its role in physiological and pathological processes. The text focuses on the most recent progress in the use of capsaicin and capsaicin-like molecules as a therapeutic agent and highlights potential pharmaceutical implications of further TRPV1 research. The chapters are written by noted experts in their fields of endeavor. This book offers both clinicians and researchers valuable resource and reference material on the subject that will stimulate future research.

1 Capsaicin and Sensory Neurones: a Historical Perspective

J?nos Szolcs?nyi

2 Pharmacology of the Capsaicin Receptor, Transient Receptor Potential Vanilloid Type 1 Ion Channel

Istvan Nagy, Dominic Friston, Jo?o Sousa Valente, Jose Torres P?rez, Anna P Andreou

3 TRPV1 in the Central Nervous System: Synaptic Plasticity, Function, and Pharmacological Implications

Jeffrey G. Edwards

4 Topical Capsaicin Formulations in the Management of Neuropathic Pain

Mark Schumacher and George Pasvankas

5 Capsaicin-Based Therapies for Pain Control

Howard Smith and John R. Brooks

6 Intranasal Capsaicin in Management of Non-allergic (Vasomotor) Rhinitis

Umesh Singh and Jonathan A. Bernstein

7 Capsaicin as an Anti-obesity Drug

Felix W. Leung

8 The Potential Antitumour Effects of Capsaicin

In?s D?az-Laviada and Nieves Rodr?guez-Henche

9 Capsalþ