Cardiac Energetics From Emax to Pressure-Volume Area [Paperback]

Most of the progress in cardiac energetics in recent years has been spurred by the pressure-volume area concept, the natural extension into energetics of earlier pioneering work delineating the time-varying elastance framework for ventricular contraction. The book draws together a broad spectrum of researchers - basic, applied and clinical - having a shared interest in the energetics of cardiac muscle and ventricle, providing an overview of the current state of the art.Most of the progress in cardiac energetics in recent years has been spurred by the pressure-volume area concept, the natural extension into energetics of earlier pioneering work delineating the time-varying elastance framework for ventricular contraction. The book draws together a broad spectrum of researchers - basic, applied and clinical - having a shared interest in the energetics of cardiac muscle and ventricle, providing an overview of the current state of the art.List of contributors. Preface; M.M. LeWinter, et al. 1. Energy costs of PVA and Emax: constancy and variability; H. Suga, et al. 2. Kinetic property of cardiac myosin in vitro; S. Sugiura, et al. 3. Thin filament regulation and cardiac energetics; R.J. Solaro. 4. Explaining load-dependent ventricular performance and energetics based on a model of E-C coupling; D. Burkhoff, et al. 5. Cardiac contractions. PVA and energetic considerations determined from a cardiac muscle crossbridge model; T.W. Taylor, et al. 6. Normalization of Emax and PVA; M. Sugawara, et al. 7. Observations on the relation of PVA and MVO2 in closed chest dogs; G.L. Freeman, S.D. Prabhu. 8. Regional myocardial contraction coupled with energetics; Y. Goto, et al. 9. Energetics during ventricular fibrillation; H. Kusuoka, E. Marbab. 10. Influence of preload on non-mechanical VO2 assessed with 2,3-butanedione monoxime; M.M. LeWinter, et al. 11. Emax and myocardial microcirculation; F. Kajiya, et al. 12. Efficiency of ventricular-arterial col3%