Cardiovascular Genomics [Hardcover]

Recognized scientists and clinicians from around the world discuss the most recent molecular approaches to understanding the cardiovascular system in both health and disease. The authors focus on all components of the system, including blood vessels, heart, kidneys, and the brain, and cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension. The methods described for identifying the genes that cause susceptibility to cardiovascular diseases emphasize the possibility of discovering new drug targets. Authoritative and ground-breaking, Cardiovascular Genomics offers an unprecedented examination of both the cutting-edge scientific approaches now possible and the results obtained from them in the new science of cardiovascular genomics.Recognized scientists and clinicians from around the world discuss the most recent molecular approaches to understanding the cardiovascular system in both health and disease. The authors focus on all components of the system, including blood vessels, heart, kidneys, and the brain, and cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension. The methods described for identifying the genes that cause susceptibility to cardiovascular diseases emphasize the possibility of discovering new drug targets. Authoritative and ground-breaking, Cardiovascular Genomics offers an unprecedented examination of both the cutting-edge scientific approaches now possible and the results obtained from them in the new science of cardiovascular genomics.Part I. Genes and Polymorphisms in Cardiovascular DiseaseAngiotensin II Receptor Polymorphisms and HypertensionBruno BaudinAngiotensinogen Gene Polymorphisms and HypertensionAshok KumarSubstitution Mapping: Using Congenic Strains to Detect Genes Controlling Blood PressureBina Joe and Michael R. GarrettLocal Production of Angiotensinogen: Insights From Genetic Manipulation of MiceKamal Rahmouni and Curt D. SigmundCardiovascular PharmacogenomiclS!