A Case Approach to Perioperative Drug-Drug Interactions [Paperback]

The occurrence of deleterious or even fatal?drug-drug interactions (DDIs)?in the perioperative period is no longer a theoretical concern but a harrowing reality. A Case Approach to Perioperative Drug-Drug Interactions addresses the complex realm of pharmacokinetic drug interactions in an easy-to-read volume that functions as both a comprehensive clinical reference and a casebook.? The book presents a summary of the core concepts of drug interactions; an organized, annotated presentation of the drug interactions most relevant to the perioperative clinician; and approximately 200 case scenarios that highlight specific drug interactions. This book fills a real void in the clinical literature and is invaluable to?anesthesiologists and surgeons, as well as trainees ?in both specialties; intensive care staff, including physicians, physicians assistants, and nurses; and nurse practitioners who staff preoperative evaluation clinics.?

Part I. Introduction to Drug-Drug Interactions

1. Lets Start at the Very Beginning: Overcoming Fear and Gaining Mastery of Drug-Drug Interactions

F. Jacob Seagull, PhD, Catherine Marcucci, MD

2. Pharmacodynamic Interactions:? Core Concepts

Erica D. Wittwer, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc

3. Pharmacokinetic Interactions:? Core Concepts

Erica D. Wittwer, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc

4. A Brief Treatise On The Area Under The Curve

Michael J. Sikora, MD, Barbara Jericho, MD

Part II. Introduction to Drug-Drug Interactions:? Brief Review of CYP450 Enzymes, UGTs, and Transporters

5. CYP2D6:? Where It All Began

John C. Sanders, MBBS, FRCA, Rachel Koll, MD, Randal O. Dull, MD, PhD???????????????????????????????

6. CYP2E1:? The Anesthesia Enzyme