CD137 Pathway Immunology and Diseases [Paperback]

The most practical and clinical reasons for attempting to understand the immunology of infections and disease revolves around the CD137 and CD137/41BB receptor and ligand molecules. This book covers all aspects of CD137/4-1BB pathway research from microbiology, infectious disease, molecular biology, biochemistry, and genetics to immune responses and potential applications in the diagnosis and treatment of human diseases. This pathway is emerging as one of the most important targets for manipulation of immune responses for disease diagnosis and treatment. This book is written by the man who discovered the CD-137 and B7H1 molecules in 1999.

This book covers all aspects of CD137/4-1BB pathway research. This pathway is emerging as one of the most important targets for manipulation of immune responses for disease diagnosis and treatment. The books author discovered the CD-137 and B7H1 molecules in 1999.

It is still hard to believe that manipulation of a single protein on the cell surface or an interaction of two or more proteins, which at times is collectively referred to as a pathway, could have such a profound effect on our immune system. At present, a number of such proteins or pathways have been identi?ed. These observations could only be interpreted in a way that, although tens of thousand of proteins are required for a perfectly healthy immune system, many of these pathways may work in either interconnected or linear fashion. Therefore, the combined understanding of each pathway, their interactions with other pathways, and the functional c- sequence, is a cornerstone for our interpretation of pathological basis of diseases and future treatments. It is important to stay abreast on the pace of progress, which I refer to as periodic summary of incremental and breakthrough discoveries in each pathway by the experts and the leader in the ?eld. The CD137 Pathway: Immunology and Diseases represents such an effort and this is the ?rstló»