Cell Cycle Control [Paperback]

What makes a cell begin the complicated process of cell division? How does it stop? What happens when things go wrong? The use of developing technologies has revealed the extraordinary degree to which cell cycle control mechanisms have been conserved through eukaryotic evolution. This is the first book to cover the cell cycle field in the wake of groundbreaking research from the past five years. A historical look at cell cycle findings places this new knowledge into perspective and demonstrates the universality of cell cycle control, from the evolutionary process to cancer research and mitotic regulation. Cell cycle research is the most exciting area in contemporary biology, and anyone either interested or involved in the cell cycle field will find this an invaluable study.

1. Introduction to cell cycle controls
2. A brief history of the cell cycle
3. START and the G1-S phase transition in budding yeast
4. Controlling entry into mitosis in fission yeast
5. The cdc2 kinase: structure, activation and its role at mitosis in vertebrate cells
6. Cyclin-dependent kinases: an embarrassment of riches
7. S Phase and its regulation
8. Cell cycle progression and cell growth in mammalian cells: kinetic aspects of transition events
9. Cancer and the cell cycle
10. Regulation of the cell cycle during Drosophila development

A collection of review articles written both by and for participants in the field. The chapters are clearly written and carefully referenced. --American Journal of Human Genetics

An advanced text that provides a solid conceptual framework for understanding cell-cycle regulation. . . .This book will be useful for a long time. --American Scientist

Uniformly well written and edited, and highly informative. It is a must for anyone entering this field and of high value generally for libraries and laboratories dealing with modern cell biology and problems of growth and development. -lÃ'