Cell Cycle in Development [Paperback]

This book focuses on the intersection between cell cycle regulation and embryo development. Specific modifications of the canonical cell cycle occur throughout the whole period of development and are adapted to fulfil functions coded by the developmental program. Deciphering these adaptations is essential to comprehending how living organisms develop. The aim of this book is to review the best-known modifications and adaptations of the cell cycle during development. The first chapters cover the general problems of how the cell cycle evolves, while consecutive chapters guide readers through the plethora of such phenomena. The book closes with a description of specific changes in the cell cycle of neurons in the senescent human brain. Taken together, the chapters present a panorama of species - from worms to humans - and of developmental stages - from unfertilized oocyte to aged adult.

This book thoroughly examines current understanding of processes accompanying embryonic transitions, in which cell cycle machinery is implicated. The authors explain numerous questions of how the basic cell cycle events are controlled at the cellular level.Experimental systems to explore life origin: perspectives for understanding primitive mechanisms of cell division. Evolution of bet-hedging mechanisms in cell cycle and embryo development stimulated by weak linkage of stochastic processes. Mechanics of cell shape regulation during the cell cycle. The spindle assembly checkpoint: clock or domino? Cell-size-dependent control of organelle sizes during development. The first cell cycle of the C. elegans embryo. Spatial and temporal control of an asymmetric cell division. EGG Molecules Couple the Oocyte-to-Embryo Transition with Cell Cycle Progression. Cell cycle in ascidian eggs and embryos. Regulatory Pathways Coordinating Cell Cycle Progression in Early Xenopus Development. Control of DNA replication by Cyclin-Dependent Kinases in development. Greatwl6