Cell Cycle Inhibitors in Cancer Therapy Current Strategies [Hardcover]

Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.Cdk Inhibitors: Background and IntroductionGiulia De Falco, Catherine Soprano, and Antonio Giordanop27, A Prognostic Indicator Reflecting...?Andrew KoffCell Cycle Control of Transcription at the G1/S Phase TransitionAndr? J. van Wijnen, Gary S. Stein, Janet L. Stein, and Jane B. LianTumor-Suppressor Genes as Diagnostic ToolsLorenzo Leoncini, Cristiana Bellan, Caterina Cinti, and Antonio GiordanoRegulation of Cell Cycle and ApoptosisLucio MieleCDK Inhibitors as Targets of Chemoprevention AgentsJoanna K. Sax and Wafik S. El-DeiryCell Cycle Regulatory Genes as Talcy