This volume details protocols on detection and analysis of fusion events in various cell types in vitro and in vivo. Additional, protocols aim to facilitate the future highly relevant process of engineering cells for specific purposes, such as generation of transgenic embryos and development of hybrid cells, in order to tackle specific tasks in cell biology and medicine. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Practical and authoritative, Cell Fusion: Overviews and Methods, Second Edition serves as an ideal reference on cell fusion and laboratory protocols.
. State of the Art in Cell-Cell Fusion
Lena Willkomm and Wilhelm Bloch
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2. Fusion in Cancer: An Explanatory Model for Aneuploidy, Metastasis Formatio, and Drug Resistance
Marieke Mohr, Kurt S. Zaenker, and Thomas Dittmar
?3. Mouse Embryos? Fusion for the Tetraploid Complementation AssayMarina Gertsenstein
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4. Generation of Mouse Chimeras with High Contribution of Tetraploid Embryonic Stem Cells and Embryonic Stem Cell-fibroblast Hybrid Cells
Matveeva N.M., Kizilova E.A., and Serov O.L.
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5. Microfluidic Systems for Cell Pairing and Fusion
Burak Dura and Joel Voldman
?6. Chromosome Tracking in Fused Cells by Single Nucleotide Polymorphisms
Azra Fatima and Tomo `ari
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7. Fusion of Mesenchymal Stem Cells and Islet Cells for Cell Therapy
Shoichiro Sumi MD, PhD and Goichi Yanai, MPharm
?8. Detection of Fusion l$
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